TABLE 4.

Polymyxin B susceptibility in mutant P. aeruginosa strains

P. aeruginosa strainPolymyxin B MICa (μg/ml)
PAO10.5
PAO1(ΔoprΗ-phoPQ::Gm)0.5
PAO1(ΔoprΗ-phoPQ::Gm)/pAU124 (oprH-phoPQ
    from PAO1)0.25
PAO1(ΔoprΗ-phoPQ::Gm)/pAU146 (oprH-phoPQ
    from NY214)4
PAO1(ΔoprΗ-phoPQ::Gm)/pAU147 (oprH-phoPQ
    from NY215)4
PAO1(ΔoprΗ-phoPQ::Gm)/pAU148 (oprH-phoPQ
    from NY217)4
PAO1(ΔoprΗ-phoPQ::Gm)/pAU149 (oprH-phoPQ
    from NY219)4
PAO1(ΔoprΗ-phoPQ::Gm)/pUCP18 (vector)0.25
PAO1(ΔpmrAB::Tc)0.25
PAO1(ΔpmrAB::Tc)/pAU126 (pmrAB from PAO1)≤0.25
PAO1(ΔpmrAB::Tc)/pAU154 (pmrAB from NY220)4
PAO1(ΔpmrAB::Tc)/pUCP180.25
PAO1(arnB::Tc)0.5
NY214(arnB::Tc)0.5
NY215(arnB::Tc)0.5
NY217(arnB::Tc)0.5
NY219(arnB::Tc)NDb
NY220(arnB::Tc)0.5
  • a MIC measurements were repeated three times with identical results.

  • b ND, not determined.