TABLE 2.

Activity of antimicrobial lock solutions against C. parapsilosis after 15 min of exposure in the MRD model

Drug combination testedEradication after 15 min in drug (mean CFU/ml ± SD)P value vs controlRegrowth (24-h growth after 15 min in drug) (mean CFU/ml ± SD)P value vs control
Minocycline (3 mg/ml)138 ± 1220.01500 ± 00.99
EDTA (30 mg/ml)160 ± 860.01500 ± 00.99
Ethanol (25%)0<0.01142 ± 2440.01
Minocycline (3 mg/ml), EDTA (30 mg/ml)153 ± 1770.01500 ± 0<0.01
Ethanol (25%), EDTA (30 mg/ml)0<0.010<0.01
Ethanol (25%), minocycline (3 mg/ml)0<0.0183 ± 204<0.01
Ethanol (25%), EDTA (30 mg/ml), minocycline (3 mg/ml)0<0.010<0.01
Control (MHB alone)500 ± 0500 ± 0