Cure rate of M. ulcerans infections after various durations of treatment with combination of RIF and an aminoglycoside (second experiment)
| Treatment | Cure rate (no. of mice cured/no. of mice treated [%]) for the following duration of treatment: | |||
|---|---|---|---|---|
| 2 wk | 4 wk | 8 wk | 12 wk | |
| RIF-STR | 11a/20 (55) | 15a/20 (75) | 19/19 (100) | 19/19 (100) |
| RIF-AMK | 14a/20 (70) | 19/20 (95) | 20/20 (100) | 20/20 (100) |
| Total | 25/40 (62.5) | 34/40 (85) | 39/39 (100) | 39/39 (100) |
↵a One bacteriological relapse, i.e., no rebound of lesion index but mouse M. ulcerans culture positivity by the end of follow-up, was observed in each of these groups.