TABLE 2.

Pharmacokinetic parameters for four FQs, determined with uninfected BALB/c mice, following single ascending doses

DrugDose range (mg/kg)Cmax (μg/ml)AUC0-∞ (μg · h/ml)t1/2 value (h)
OFX37.5-2,4001.7-101.229-6614.93 ± 2.6
MXF6-4000.38-9.2325-634.46 ± 0.66
CIP37.5-2,4001.2-3129-1254.74 ± 5.32
SPX5-1,0000.75-1443-1919.8 ± 5.32