TABLE 1.

Antimicrobial susceptibility patterns of P. aeruginosa and C. freundii KPC-possessing clinical isolates

Antimicrobial agent(s)MIC (μg/ml)
P. aeruginosa PA2404P. aeruginosa PA4012P. aeruginosa PA4036C. freundii CF6010
Imipenem256>256>2568
Imipenem-CLAa256>256>2564
Meropenem>256>256>2568
Meropenem-CLA>256>256>2562
Ertapenem>256256>25616
Ampicillin>256>256>256>256
Ampicillin-SULb>256>256>256>256
Piperacillin>256>256>256>256
Piperacillin-TZBc>256>256>256>256
Ceftazidime25625625632
Cefotaxime>256>256>25632
Ceftriaxone>256>256>256256
Cefepime>256>256>2568
Aztreonam>256>256>256128
Aztreonam-CLA>256>256>256128
Amikacin1616162
Gentamicin>128>128>128>128
Tobramycin>128>128>12864
Tigecyclined1616160.5
Colistin1210.5
  • a CLA, clavulanic acid; inhibitor tested at a fixed concentration of 2 μg/ml.

  • b SUL, sulbactam. Penicillin/inhibitor ratio, 2:1.

  • c TZB, tazobactam; inhibitor tested at a fixed concentration of 4 μg/ml.

  • d Tested in CA-MHB medium <12 h old.