TABLE 5.

Activity of EDP-420 in combination with mefloquine against clarithromycin-resistant M. avium 101 in mice

RegimenaDose (mg/kg)Mice (n)Bacterial load (CFU/g ± SEM) in:
LiverSpleen
Mefloquine40222.9 × 107 ± 0.9 × 107b4.6 × 107 ± 0.6 × 107b
EDP-420100152.5 × 108 ± 1.6 × 1082.7 × 108 ± 1.0 × 108
Mefloquine + EDP-42040 + 100142.9 × 107 ± 1.9 × 107b4.9 × 107 ± 2.0 × 107b
Untreated control151.4 × 108 ± 0.4 × 1085.6 × 108 ± 1.5 × 108
Baseline (7 days)84.5 × 107 ± 1.9 × 1079.5 × 107 ± 3.0 × 107
  • a Mice were treated once a day, 6 days a week, for 4 weeks.

  • b P < 0.5 compared with untreated control.