TABLE 4.

Activity of EDP-420 in combination with mefloquine against M. avium in mice

RegimenaDose (mg/kg)Mice (n)Bacterial load (CFU/g ± SEM) in:
LiverSpleen
Mefloquine40131.8 × 107 ± 0.7 × 107b4.8 × 107 ± 2.2 × 107b
EDP-420100151.2 × 107 ± 0.4 × 107b1.7 × 107 ± 0.5 × 107b
Mefloquine + EDP-42040 + 100141.3 × 107 ± 0.4 × 107b1.6 × 107 ± 0.6 × 107b
Untreated control151.1 × 109 ± 0.4 × 1092.4 × 109 ± 0.9 × 109
Baseline (7 days)92.5 × 107 ± 1.3 × 1071.2 × 108 ± 0.9 × 108
  • a Mice were treated daily, 6 days a week, for 4 weeks.

  • b P < 0.05 compared with untreated control.