TABLE 2.

Effect of the treatment of MAC 101-infected beige mice with EDP-420

RegimenaDosebBacterial load (CFU/g) in:
LiverSpleen
Clarithromycin100 mg/kg2.8 × 107 ± 0.6 × 107c6.6 × 107 ± 1.2 × 107c
EDP-420100 mg/kg7.1 × 106 ± 1.4 × 106c,d1.2 × 107 ± 0.3 × 107c,d
Untreated control8.0 × 108 ± 1.8 × 1082.7 × 109 ± 0.4 × 109
Baseline control (1 week)2.4 × 108 ± 1.4 × 1087.0 × 108 ± 3.1 × 108
  • a Mice were treated daily for 6 days during 4 weeks.

  • b Mice were infected intravenously, and 1 week after infection 10 mice were harvested and the level of infection before therapy was established. Twenty mice were used for the experimental group.

  • c P < 0.05 compared with untreated control.

  • d P < 0.05 compared with clarithromycin.