TABLE 3.

Effect of treatment of clarithromycin-resistant M. avium strain 101 with EDP-420

RegimenbDoseBacterial load (CFU/g ± SEM) ina:
LivercSpleenc
Clarithromycin100 mg/kg2.8 × 108 ± 0.4 × 1088.0 × 108 ± 1.3 × 108
EDP-420100 mg/kg1.7 × 108 ± 0.2 × 1085.7 × 108 ± 0.8 × 108
Untreated control2.4 × 108 ± 0.5 × 1086.2 × 108 ± 1.3 × 108
Baseline control (1 week)8.7 × 107 ± 1.5 × 1072.1 × 108 ± 0.5 × 108
  • a Mice were infected intravenously, and 1 week after infection 10 mice were harvested and the level of infection before therapy was established. Twenty animals were used in each experimental group.

  • b Mice were treated once a day, 6 days a week, for 4 weeks.

  • c P > 0.05 for all comparisons.