TABLE 6.

Frequency of resistance to EDP-420 and EDP-420/mefloquine

Experimental groupMice (n)CFU/g of spleenFrequency of resistance to EDP-420
8 week control247.0 × 109 ± 1.6 × 109∼10−9
8 week EDP-420272.3 × 105 ± 0.8 × 105Undetected
8 week EDP-420 + mefloquine221.2 × 105 ± 0.3 × 105Undetected
12 week control214.6 × 109 ± 1.5 × 109∼10−9
12 week EDP-420272.5 × 105 ± 1.1 × 105Undetected
12 week EDP-420 + mefloquine201.1 × 105 ± 0.5 × 105Undetected