TABLE 1.

In vitro susceptibility of M. avium strains to EDP-420, azithromycin, clarithromycin, and telithromycin

DrugMIC for M. avium macrolide-susceptible strains (n = 24) (μg/ml)MIC range for M. avium macrolide-resistant strains (n = 6) (μg/ml)
Range50%90%
EDP-4202-84832-64
Azithromycin8-161616>512
Clarithromycin0.5-424>64
Telithromycin32-64a32>64NAb
  • a The MIC range for telithromycin reported here is one dilution different from previous results, probably due to different lots of medium and albumin.

  • b NA, not available.