TABLE 2.

Pharmacodynamic effects of polymyxin B and tigecycline plus polymyxin B against CIRA

Expt no.Polymyxin B (2 mg/liter)Tigecycline (0.125 mg/liter) + polymyxin B (2 mg/liter)Interpretation
Log10 CFU/ml at time zeroLog10 CFU/ml at time 24 hChange in log10 CFU/ml from time zero to 24 hLog10 CFU/ml at time zeroLog10 CFU/ml at time 24 hChange in log10 CFU/ml from time zero to 24 h
15.523.95−1.57NAaNANANA
25.201.60−3.65.443.99−1.45Antagonism
35.204.64−0.565.011.60−3.41Enhancement
45.306.34+1.045.261.60−3.65Bactericidal
55.362.20−3.165.445.76+0.32Antagonism
  • a NA, not applicable.