TABLE 4.

Risk factors associated with 21-day mortality (univariate analysis)

VariableNo. (%) of patientsaOR (95% CI)P
Nonsurvivors (n = 71)Survivors (n = 115)
Patient-related
    Male sex38 (53.5)69 (60)0.76 (0.40-1.45)0.38
    Mean age in yr ± SD55 ± 2054 ± 190.83
    Baseline clinical characteristics
        Chronic renal failure21 (29.6)32 (27.8)1.08 (0.53-2.19)0.79
        Dialysis19 (26.7)31 (26.9)0.99 (0.47-2.02)0.97
        Diabetes20 (28.2)30 (26.1)1.11 (0.53-2.26)0.75
        Hematological malignancy12 (16.9)33 (28.7)0.50 (0.21-1.10)0.06
        Liver disease15 (21.1)11 (9%)2.53 (1.00-6.51)0.02
        Solid tumor20 (28.1)32 (27.8)1.01 (0.49-2.05)0.95
        Mean Charlson index ± SD3.4 ± 2.13.2 ± 1.50.78
        Intensive care unit stay at time of BSI19 (26.8)36 (31.3)0.80 (0.39-1.61)0.50
        Invasive procedures29 (40.8)42 (36.5)1.20 (0.64-2.29)0.55
        Immunosuppressive therapy18 (25.3)39 (33.3)0.66 (0.32-1.33)0.21
        Neutropenia6 (8.4)16 (13.9)0.57 (0.17-1.64)0.39
        Surgery19 (26.8)30 (26.1)1.03 (0.49-2.12)0.91
        Mean days in hospital ± SD27 ± 1526 ± 60.97
        Prior exposure to antimicrobial therapy45 (63.3)68 (59.1)1.19 (0.62-2.31)0.56
        Previous hospitalization45 (63.4)49 (42.6)2.33 (1.21-4.49)0.005
        Admission from a nursing home6 (8.4)5 (4.3)1.46 (0.82-2.60)0.24
Infection related
    Health care acquired65 (91.5)103 (89.6)1.26 (0.41-4.30)0.65
    Mean APACHE III score ± SD36 ± 1831 ± 12-0.03
    Presentation with septic shock8 (11.3)2 (1.7)7.17 (1.35-70.63)0.005
    Unknown source of BSI45 (63.4)41 (35.6)3.12 (1.61-6.06)<0.001
Treatment related
    Inadequate initial antimicrobial treatment53 (74.6)36 (31.3)6.46 (3.17-13.33)<0.001
Microorganism related
    E. coli33 (46.5)71 (61.7)0.53 (0.28-1.02)0.04
    K. pneumoniae28 (39.4)30 (26.1)1.84 (0.93-3.64)0.05
    P. mirabilis10 (14.1)14 (12.2)1.18 (0.74-2.68)0.70
    Multidrug resistant31 (43.6)18 (15.6)4.17 (1.99-8.84)<0.001
    Multiple β-lactamase production23 (32.3)23 (20)1.91 (0.92-3.97)0.05
  • a All values are presented as “no. (%) of patients” except as noted otherwise in column 1.