TABLE 2.

Effect of 50% serum on caspofungin and micafungin MECsa of Aspergillus spp.

Aspergillus sp. (nb)Result for drug
CaspofunginAnidulafunginMicafungin
MIC50Fold changeMIC50Fold changeMIC50Fold change
−Serum+50% serum−Serum+50% serum−Serum+50% serum
A. fumigatus (10)<0.25 (0.016-0.25)1 (0.5-2.0)11 (2-67)0.0156 (0.016)0.5 (0.25-2.0)32 (32-128)0.0156 (0.0156)1 (0.5-2.0)64 (33-133)
A. flavus (7)0.03 (0.016-0.06)0.5 (0.125-0.5)8 (4-17)0.0156 (0.016)0.5 (0.125-1.0)32 (16-64)0.0156 (0.0156)0.5 (0.5-2.0)33 (17-33)
A. niger (8)0.06 (0.06-0.25)1.0 (0.5-1.0)8 (4-17)0.0156 (0.0156)0.5 (0.25-0.5)32 (16-32)0.0156 (0.0156)2 (0.5-2.0)133 (33-133)
A. terreus (9)0.125 (0.03-0.5)0.5 (0.25-0.5)4 (1-8)0.0156 (0.0156)0.25 (0.125-0.25)16 (8-16)0.0156 (0.0156)0.5 (0.125-0.5)32 (4-32)
  • a MEC is defined as the lowest concentration of drug producing a macroscopically visible morphological change. For an explanation of values, see footnote a of Table 1.

  • b n, no. of isolates.