TABLE 5.

Effects of OprD on spermine-dependent antibiotic susceptibility in P. aeruginosa

Strain (description)aMIC (μg/ml)b for indicated antibiotic and treatment
ImipenemCarbenicillinPolymyxin B
NoneSpNNoneSpNNoneSpN
DK100 (Smr)4326440.54
DK101 (Smr; oprD::Gm)32326420.54
DK101/pAU480.5326420.54
  • a Smr, streptomycin resistance; Gm, gentamicin resistance cassette. Plasmid pAU48 carries an intact oprD gene.

  • b MIC measurements were done in the absence (none) or presence of 10 mM spermine (SpN).