TABLE 2.

MBCs and MBC/MIC ratios of BAL19403 and comparator drugs for some P. acnes strains

P. acnes strainResistance phenotype and resistance mechanism(s)MBC (μg/ml [MBC/MIC ratio])
BAL19403ErythromycinClindamycinTetracycline
EG7NSErys Clis Tets≤0.06a>32 (≥533)>32 (≥533)>32 (≥533)
SW3CDErys Clir Tets (unknown)≤0.06a0.125 (≥2)>32 (>4)>32 (>32)
P95Eryr Clir Tets (G2057A)≤0.06a>32 (>8)32 (>64)32 (>64)
SW101TEryr Clir Tetr (A2058G + G1058C)>32 (>8)b>512 (>2)>32 (>1)
GE4EErmX≥256 (≥2)>32 (>16)
  • a The MIC and the MBC were each at or below the minimum value of the range tested.

  • b —, MIC > 512 μg/ml.