TABLE 1.

Effect of 50% serum on echinocandin MICsa of Candida spp.

Candida sp. (nb)Result for drug
CaspofunginAnidulafunginMicafungin
MIC50Fold changeMIC50Fold changeMIC50Fold change
−Serum+50% serum−Serum+50% serum−Serum+50% serum
C. albicans (47)≤0.25 (0.0156-0.5)0.5 (0.03-2.0)2 (1-16)0.0156 (0.0156)0.25 (0.125-4.0)16 (8-256)0.0156 (0.0156)1 (0.5-2.0)64 (32-128)
C. glabrata c 0.5 (0.25-0.5)1 (1.0-2.0)4 (2.0-4.0)0.0156 (0.0156-0.125)1 (0.5-2)64 (16-64)0.0156 (0.015)1 (1)64 (64)
C. krusei (10)≤1 (0.25-2.0)8 (0.5-16.0)8 (2.0-16.0)0.25 (0.0156-0.25)8 (2.0-16.0)32 (16-256)0.06 (0.015-0.06)8 (2.0-16.0)133 (8-267)
C. parapsilosis (10)1 (0.5-2.0)4 (2-16.0)4 (2-8)2 (1-4)16 (16)8 (4-16)1 (0.125-2.0)16 (16)16-128 (8-128)
C. tropicalis (10)0.125 (0.015-0.25)0.5 (0.125-0.5)4 (1-33)0.0156 (0.0156-0.031)2 (0.125-2.0)128 (8-128)0.0156 (0.0156)2 (0.5-4.0)128 (8-256)
  • a All values represent averages for triplicate experiments with less than 15% variance. Numbers in parentheses represent n-fold changes relative to values for the zero-serum control.

  • b n, no. of isolates.

  • c C. glabrata strains grew poorly in human serum. Therefore, mouse serum (Pel-Freez, Rogers, AR) was used. −Serum, no serum.