TABLE 3.

Summary of time-kill test results for BAL19403 and comparator drugs for P. acnes

Drug and concn (multiple of MIC)No. of strains killed at the indicated level/no. of strains tested at the following timea:
6 h12 h24 h
0−1−2−30−1−2−30−1−2−3
BAL19403
    25/61/60/60/64/62/60/60/63/63/60/60/6
    44/62/60/60/63/63/60/60/61/62/62/61/6
    85/61/60/60/63/62/61/60/61/63/61/61/6
Erythromycinb
    23/30/30/30/33/30/30/30/32/31/30/30/3
    43/30/30/30/32/31/30/30/32/31/30/30/3
    83/30/30/30/33/30/30/30/31/32/30/30/3
Clindamycinb
    23/30/30/30/33/30/30/30/32/31/30/30/3
    43/30/30/30/33/30/30/30/31/32/30/30/3
    83/30/30/30/33/30/30/30/31/32/30/30/3
Tetracyclinec
    24/40/40/40/44/40/40/40/44/40/40/40/4
    44/40/40/40/44/40/40/40/44/40/40/40/4
    84/40/40/40/44/40/40/40/44/40/40/40/4
Cefoxitin
    26/60/60/60/65/61/60/60/62/62/62/60/6
    46/60/60/60/64/62/60/60/62/61/61/62/6
    84/62/60/60/63/62/61/60/62/60/61/63/6
  • a 0, <90% killing; −1, 90 to <99% killing; −2, 99 to <99.9% killing; −3, ≥99.9% killing.

  • b Only three strains were tested by the time-kill method.

  • c Only four strains were tested by the time-kill method.