TABLE 1.

Protection studies: efficacy of phage therapy on P. aeruginosa infection of burn wounds

TreatmentNo. of survivors/total no. of mice (% survival)a
Expt 1Expt 2Expt 3Combined exptb
48 hpi72 hpi48 hpi72 hpi48 hpi72 hpi48 hpi72 hpi
PAO1 only0/6 (0)0/6 (0)1/6 (16.7)0/6 (0)2/6 (33.3)1/6 (16.7)3/18 (17)1/18 (6)
Phage by i.p. route only6/6 (100)6/6 (100)6/6 (100)6/6 (100)6/6 (100)6/6 (100)18/18 (100)18/18 (100)
Phage by i.m. route only6/6 (100)6/6 (100)6/6 (100)6/6 (100)6/6 (100)6/6 (100)18/18 (100)18/18 (100)
Phage by s.c. route only6/6 (100)6/6 (100)6/6 (100)6/6 (100)6/6 (100)6/6 (100)18/18 (100)18/18 (100)
Phage by i.p. route + PAO1 infection6/6 (100)5/6 (83.3)6/6 (100)6/6 (100)5/5 (100)4/5 (80)17/17 (100)c15/17 (88)e
Phage by i.m. route + PAO1 infection3/6 (50)2/6 (33.3)3/6 (50)0/6 (0)4/6 (66.7)3/6 (50)10/18 (56)d5/18 (28)
Phage by s.c. route + PAO1 infection2/6 (33.3)2/6 (33.3)3/6 (50)0/6 (0)5/6 (83.3)2/6 (33.3)10/18 (56)d4/18 (22)
  • a The cumulative survival was determined at 48 h and 72 hpi.

  • b The average percent survival of animals in three experiments determined at 48 and 72 hpi.

  • c The rate of survival for animals receiving the phage cocktail i.p. was significantly greater (P < 0.0001) than that for untreated infected control animals at the same time period.

  • d The rate of survival for animals receiving the phage cocktail i.p. was significantly greater (P < 0.01) than that for untreated infected control animals at the same time period.

  • e The rate of survival for animals receiving the phage cocktail i.p. was significantly greater (P < 0.0026) than that for untreated infected control animals at the same time period.