TABLE 1.

Demographic and clinical characteristics of patients in colistin and control groups

CharacteristicColistin group (n = 31)Control group (n = 64)P value
Median (range) age (yr)52 (10-72)62 (3-82)0.012
Sex (no. [%] of patients)
    Male22 (71)40 (62)0.42
    Female9 (29)24 (38)
Underlying disease (no. [%] of patients)0.033
    Leukemia20 (64)24 (38)
    Lymphoma/myeloma4 (13)9 (14)
    Solid tumor7 (23)31 (48)
ICU stay (no. [%] of patients):
    Within 30 days prior to infection17 (55)30 (47)0.47
    During infection21 (68)37 (58)0.35
Median (range) APACHE II score17 (11-27)16 (7-32)0.38
No. (%) of patients with:
    Mechanical ventilation within prior mo15 (48)28 (44)0.67
    Hemodialysis within prior mo8 (26)8 (12)0.10
    Neutropenia within 30 days prior to infection17 (55)30 (47)0.47
Median (range) duration (days) of neutropenia within 30 days prior to infection(3-31)(1-122)0.89
Neutropenia during infection (no. [%] of patients)14 (45)24 (37)0.48
Median (range) duration (days) of neutropenia during infection(2-118)(2-100)0.32
No. (%) of patients with:
    Pseudomonas infection or colonization (within prior year)13 (42)31 (48)0.55
    Polymicrobial infection16 (52)30 (47)0.67
    Hospital admission within 30 days prior to infection30 (97)39 (61)0.0002
    Nosocomial infection27 (87)41 (64)0.02
    Antibiotic resistance
        Three classes7 (23)18 (28)0.57
        Four classes7 (23)26 (41)0.083
        Five classes16 (52)10 (16)0.0002
    Bacteremia14 (45)22 (34)0.31
    Pneumonia17 (55)30 (47)0.47
    UTI07 (11)0.056
    Wound05 (8)0.17
Median (range) treatment duration (days)20 (5-58)20 (3-120)0.53