TABLE 3.

Differences between the amino acid sequences of the adeR and adeS gene products for the indicated strainsa

StrainAmino acid at indicated position of protein encoded by indicated gene
adeRadeS
1201421585960186227245279293327
D54VIHVDGDIASV
A24ILHVDVDVVGV
B46ILLIDGHVAGE
C75ILLIYGHVAGV
BM4454ILHVDVDVVGV
  • a The strains used were a tigecycline-susceptible laboratory strain (D54), a clinical strain (A24), two tigecycline-nonsusceptible clinical strains (B46 and C75), and a previously sequenced Acinetobacter baumannii isolate found to have overexpression of the AdeABC pump (BM4454) (9, 10). V, valine; A, alanine; I, isoleucine; D, aspartic acid; Y, tyrosine; G, glycine; H, histidine; L, leucine; S, serine; and E, glutamic acid.