TABLE 4.

MICs of various compounds against S. aureus rplC/unmapped mutants and their fast-growing variants

StrainAlteration(s)MIC (μg/ml) ofa:
REPTIACMTCLEV
RN4220None≤0.060.2540.250.5
2A1L3 G152D D159Y11680.250.25
2A1-1L3 G152D D159Y + unmapped8648≤0.060.25
2A1-7L3 G152D D159Y + unmapped8644≤0.060.25
2A1-8L3 G152D D159Y + unmapped2324≤0.060.25
2A1-1 fast1L3 D159Y + unmapped0.25280.250.5
2A1-1 fast2L3 D159Y + unmapped0.25280.250.25
2A1-7 fast1L3 D159Y + unmapped0.25280.250.25
2A1-7 fast2L3 D159Y + unmapped0.25280.250.25
  • a Abreviations: REP, retapamulin; TIA, tiamulin; CM, chloramphenicol; TC, tetracycline; LEV, levofloxacin.