TABLE 1.

Distribution of MICs of BAL19403 and comparator drugs for propionibacterial clinical isolates as a function of resistance phenotype

Resistance phenotype and mechanism(s)	Strain	MIC (μg/ml)^a
Resistance phenotype and mechanism(s)	Strain	BAL19403	Erythromycin	Clindamycin	Tetracycline
Ery^s Cli^s Tet^s	SW10	≤0.06	≤0.06	0.125	0.5
	SW16	≤0.06	≤0.06	≤0.06	0.25
	SW17	≤0.06	≤0.06	≤0.06	0.25
	SW26	≤0.06	≤0.06	≤0.06	0.5
	D-04/97	≤0.06	≤0.06	0.125	1
	QK8/97	≤0.06	0.125	0.125	0.5
	EG7NS	≤0.06	≤0.06	≤0.06	≤0.06
	EG13NS	≤0.06	≤0.06	≤0.06	1
	NCTC11865^b	≤0.06	0.125	≤0.06	0.5
Ery^s Cli^r Tet^s,r (unknown^c)	SW11	≤0.06	0.125	0.5	2
	EG3NS	≤0.06	≤0.06	0.25	0.5
	SW3CD	≤0.06	≤0.06	8	1
Ery^r Cli^r Tet^s,r (G2057A ± G1058C)	P95	≤0.06	4	0.5	0.5
	P401:5	≤0.06	2	1	32
Ery^r Cli^r Tet^s,r (A2058G ± G1058C)	P425:1	4	>512	512	16
	P429:1 (SC)	≤0.06	4	4	≥32
	P429:1 (BC)	0.5	2	8	1
	SW54EA	0.5	>512	32	0.5
	SW101T	4	>512	256	32
Ery^r Cli^r Tet^s,r (A2059G ± G1058C)	GE46EB^d	256	>512	512	1
	EG7E	0.5	>512	≥32	32
Ery^r Cli^r Tet^s,r (ErmX)	GE4E	128	>512	>512	2
	SP64E	≥256	>512	>512	1
	SW101CDA	64	>512	≥512	≤0.06
Ery^s Cli^s Tet^r (G1058C)	P:413	≤0.06	≤0.06	≤0.06	16
Ery^r Cli^r Tet^s (unknown^c)	QK6/92^b	0.125	0.5	1	1
Ery^r Cli^r Tet^r (unknown^c)	P322:2	0.25	>512	4	32

↵a The adopted resistance breakpoints are as follows: erythromycin, ≥0.5 μg/ml; clindamycin, ≥0.25 μg/ml; tetracycline, ≥2 μg/ml (26, 27).
↵b P. granulosum; all other strains are P. acnes.
↵c The genetic basis of antibiotic resistance is unknown.
↵d Additional mutations contributing to BAL19403 resistance are unknown.