TABLE 3.

Prevalence and frequency distribution of specific rt variants in LMVr clinical HBV isolatesa

VariantAmino acid substitutions in rtNo. (%) of isolates of the following genotype with the indicated changes:Fraction (%) of all LMVr isolates
M204L180L80ABCDEFGAll
Resistance conferred by rtM204IbI152723300019620
IM312317000449
II02030150006513
IMI041410000286
IV0664000163
IMV0244000102
    Genotype total18601008000125953
Resistance conferred by rtM204VcV10100002<1
VM6537633710721043
VMI005200071
VMV0644000143
    Genotype total6643734310723347
Genotype total (no.) for rtM204II/V84103173123108492100
Frequency (%) of rtL80V/I03736320028
  • a Data are from the SEQHEPB database. LMVr, lamividine resistant. Only the most recent LMV-resistant isolate from each patient was included.

  • b A total of 119/259 (46%) isolates coselected rtL80V/I.

  • c A total of 21/233 (9%) isolates coselected rtL80V/I.