TABLE 1.

Drug susceptibilities of C. albicans strains grown and tested under various conditions

Strain and cell population testedNo. of cells/mlMIC80 (μg/ml) of selected druga:
FluconazoleKetoconazoleAmphotericin BCaspofunginb
SC5314
    Planktonic1 × 1030.50.1250.1250.25
1 × 108>256>512>32>32
    Biofilm
        Dissociated1 × 1030.250.50.50.5
1 × 108>256>512>32>32
        Intact>512>512>32>32
GDH2346
    Planktonic1 × 10320.250.1250.125
1 × 108>512>512>32>32
    Biofilm
        Dissociated1 × 1030.250.1250.50.25
1 × 108>64>64>32>32
        Intact>512>51232>32
FH1
    Planktonic1 × 103440.1250.5
1 × 108>512>512>32>32
    Biofilm
        Dissociated1 × 1032-440.1250.5
1 × 108>512>512>32>32
        Intact>512>512>32>32
FH5
    Planktonic1 × 10364640.250.5
1 × 108>512>256>32>32
    Biofilm
        Dissociated1 × 10364640.250.5
1 × 108>512>512>32>32
        Intact>512>512>32>32
DSY1050
    Planktonic1 × 1030.250.250.250.25
1 × 108>64>256>32>32
    Biofilm
        Dissociated1 × 1030.1250.1250.250.25
1 × 108>64>64>32>32
        Intact>64>64>32>32
CHK21
    Planktonic1 × 1030.1250.1250.1250.5
1 × 108>64>64>32>32
    Biofilm
        Dissociated1 × 1030.1250.1250.250.5
1 × 108>64>64>32>32
        Intact>64>64>32>32
  • a Where MIC80 was not observed at the highest drug concentration tested, the MIC80 is indicated as “>” than the highest tested concentration.

  • b Determined at 24 h.