TABLE 2.

Treatment of experimental endocarditis caused by ATCC 700788 and HIP 5836 strainsa

Treatment groupbNo. surviving/total (%)No. with sterile vegetation/total (%)Median log CFU/g of vegetation (interquartile range)
GISA ATCC 700788
    Control0/17 (0)9.5 (8.3-9.8)
    Telavancin16/17 (94)6/16 (37)*4.6 (2.0-5.8)†
    Vancomycin20/23 (87)4/20 (20)*6.6 (2.0-6.9)†
HIP 5836
    Control0/20 (0)9.1 (9.1-9.4)
    Telavancin16/17 (94)5/16 (31)*4.4 (2.0-7.4)‡
    Vancomycin15/15 (100)1/15 (7)*6.7 (4.5-8.7)‡
  • a *, not significant; †, P = 0.05; ‡, P = 0.09.

  • b Results for telavancin represent simulation of a dose of 10 mg/kg every 24 h i.v. Results for vancomycin represent simulation of a dose of 1 g every 12 h i.v.