TABLE 1.

Pharmacokinetic parameters

ParameteraResult for:
VancomycinTelavancin
Dose 1Dose 2
Humansb
    Dose1 g i.v.7.5 mg/kg i.v.10 mg/kg i.v.
    Cmax/Cmin (μg/ml)52/1089/6
    k (h−1)0.150.1100.095
    t1/2β (h)4.66.187.41
    AUC (μg·h/ml)358.6604785
    Protein binding (%)509090
Animals (n = 5)
    Dose25 mg/kg i.v.15 mg/kg i.v.
    k (h−1)0.53 ± 0.140.57 ± 0.06
    t1/2β (h)1.3 ± 0.41.2 ± 0.11
    AUC (μg·h/ml)101 ± 16269.8 ± 52.2
    Protein binding (%)659090
Humanlike (n = 3 or 5)
    Dose1 g i.v.7.5 mg/kg i.v.10 mg/kg i.v.
    k (h−1)0.18 ± 0.030.19 ± 0.09NDc
    t1/2β (h)3.8 ± 1.24.6 ± 2.8ND
    AUC (μg·h/ml)298.8 ± 18638 ± 38ND
    Cmax/Cmin (μg/ml)46/690/6114/6
    AUC/MIC
    HIP 583637.3159.5
    ATCC70078837.3638
  • a k, first-order elimination rate constant; t1/2β, half-life at β phase; AUC, area under the concentration-time curve; Cmax, maximum concentration of drug; Cmin, minimum concentration of drug.

  • b Vancomycin values were obtained from Blouin and colleagues (4); telavancin values were obtained from data on file at Theravance, Inc.

  • c ND, not determined. Infusion parameters for the 10-mg/kg i.v. human dose were projected from the pharmacokinetic data obtained from the simulated 7.5-mg/kg i.v. human dose.