TABLE 1.

Weight loss in mice infected with influenza virus (A/Japan/305/57) given gemfibrozil once daily from days 4 to 10 after virus exposure

Gemfibrozil dose (mg/kg/day)No. of mice that survived/totalAvg % day 0 body wt ± SD on indicated day p.i. (no. of mice remaining on that day)
4681012
01/986.8 ± 4.0 (9)76.0 ± 3.4 (6)68.9 ± 3.7 (3)69.1 ± 8.5 (2)71.1 ± 12.7 (2)a
203/1087.9 ± 6.3 (10)77.5 ± 6.0 (8)75.1 ± 3.6 (5)75.2 ± 7.7 (4)79.0 ± 13.1 (4)b
404/987.0 ± 5.3 (9)75.6 ± 5.3 (9)72.2 ± 12.8 (6)73.4 ± 16.2 (5)77.1 ± 17.2 (4)
605/1086.5 ± 4.6 (10)77.1 ± 4.5 (9)73.2 ± 9.3 (7)78.0 ± 11.9 (5)81.8 ± 14.4 (5)
  • a After day 12 there was one more death, on day 17.

  • b After day 12 there was one more death, on day 14.