TABLE 1.

MICs of tested medical and agriculture azoles for yeast isolates from the oropharynges of HIV-infected patients and for environmental strains

Species (no. of isolates)Source(s) or description of isolate(s)Median (range) MIC50a (μg/ml) of:
KTCFLCITCVRCFLQPCZTCZTDL
C. albicans (4)HIV-infected patients before FLC therapy0.25 (0.25-0.5)2.25 (0.5-8)0.06 (0.03-0.06)0.03 (0.03)0.375 (0.25-64)0.25 (0.25-8)0.75 (0.5-8)2 (2-8)
C. albicans (12)HIV-infected patients during FLC therapy2 (0.25-4)128 (2-128)0.75 (0.12-32)1.5 (0.03-32)64 (0.25-128)12 (0.25-128)24 (0.5-128)64 (2-128)
C. albicans (14)Animals0.5 (0.25-4)0.25 (0.12-256)0.12 (0.06-0.5)0.03 (0.03-32)0.5 (0.12-32)2 (1-64)0.185 (0.06-64)1.5 (1-32)
C. albicans (3)Control strains0.03 (0.03)0.12 (0.06-0.5)0.06 (0.06-0.12)0.03 (0.03-0.06)0.5 (0.25-1)2 (1-2)0.06 (0.06-64)2 (0.5-2)
C. glabrata (1)Feedingstuff4 (4)32 (32)1 (1)0.25 (0.25)1 (1)4 (4)2 (2)8 (8)
C. glabrata (1)Control strain ATCC 900308 (8)8 (8)4 (4)2 (2)32 (32)4 (4)8 (8)8 (8)
C. krusei (7)Grapes and feedingstuff8 (4-8)64 (64)1 (1)1 (1-2)128 (64-128)128 (32-128)64 (32-64)64 (64-128)
C. krusei (1)Control strain ATCC 62582 (2)64 (64)0.5 (0.5)1 (1)128 (128)64 (64)32 (32)32 (32)
C. lambica (5)Grapes4 (2-4)128 (64-256)2 (2)2 (1-8)64 (64)64 (64-128)16 (8-16)128 (128)
C. norvegensis (1)Grapes2 (2)128 (128)1 (1)2 (2)64 (64)64 (64)4 (4)64 (64)
C. parapsilosis (1)Control strain ATCC 220130.12 (0.12)2 (2)0.25 (0.25)0.06 (0.06)2 (2)8 (8)1 (1)16 (16)
C. rugosa (1)Feedingstuff0.25 (0.25)1 (1)0.06 (0.06)0.03 (0.03)0.12 (0.12)1 (1)0.06 (0.06)1 (1)
C. stellata (9)Grapes8 (2-8)64 (32-64)2 (2-4)1 (1-2)64 (32-64)96 (64-128)64 (16-64)128 (128)
C. albidus (3)Grapes8 (8)64 (32-256)32 (2-32)8 (2-16)8 (8-128)128 (128)64 (8-128)128 (128)
C. neoformans (1)Control strain ATCC 901122 (2)8 (8)0.5 (0.5)0.25 (0.25)0.12 (0.12)4 (4)4 (4)4 (4)
P. anomala (1)Grapes1 (1)2 (2)0.5 (0.5)0.25 (0.25)4 (4)8 (8)4 (4)16 (16)
K. apiculata (1)Grapes0.25 (0.25)0.5 (0.5)0.25 (0.25)0.03 (0.03)0.12 (0.12)0.5 (0.5)0.06 (0.06)0.25 (0.25)
Rhodotorula sp. (1)Grapes0.5 (0.5)16 (16)0.06 (0.06)0.06 (0.06)0.5 (0.5)16 (16)1 (1)64 (64)
S. cerevisiae (9)Grapes2 (1-4)8 (4-16)2 (0.5-2)0.5 (0.25-0.5)0.25 (0.25-4)2 (0.5-16)1 (0.25-2)8 (1-16)
S. guttulata (1)Feedingstuff2 (2)1 (1)0.5 (0.5)0.12 (0.12)64 (64)8 (8)4 (4)16 (16)
  • a MIC50, MIC at which 50% of the isolates tested are inhibited.