TABLE 1.

Antimicrobial susceptibilities of 125 erythromycin-resistant S. pneumoniae strains

AntibioticMIC50 (μg/ml)MIC90 (μg/ml)MIC range (μg/ml)% Intermediate isolates% Resistant isolatesCLSI breakpoint (μg/ml)a
SensitiveIntermediateResistant
Penicillin12≤0.016-847.227.2≤0.060.12-1≥2
Amoxicillin-clavulanic acid≤0.5/0.252/1≤0.5/0.25-8/44.06.4≤2/14/2≥8/4
Cefotaxime0.250.5≤0.06-42.40.8≤12≥4
Cotrimoxazole2/38>2/38≤0.5/9.5->2/380.868.0≤0.5/9.51/19-2/38≥4/76
Tetracycline>4>4≤2->42.477.6≤24≥8
Chloramphenicol2>8≤2->8034.4≤4≥8
Levofloxacin11≤0.5->404.0≤24≥8
Moxifloxacin≤0.25≤0.25≤0.25->11.62.4≤12≥4
Erythromycin>32>324->320100≤0.250.5≥1
Azithromycin>4>4>40100≤0.51≥2
Josamycin>2>2≤0.5->2087.2≤1≥4
Clindamycin>0.5>0.5≤0.25->0.5087.2≤0.250.5≥1
Vancomycin≤0.251≤0.25-100≤1
Quinupristin-dalfopristin≤1≤1≤100≤12≥4
Telithromycin0.030.250.03-0.500≤12≥4
  • a Except for josamycin breakpoints, which were obtained from Société Frana̧ise de Microbiologie (www.sfm.asso.fr ).