TABLE 1.

Chitosan malate inhibits growth of S. aureus and, independently, SAg and delta-hemolysin production in broth cultures

S. aureus strain (SAg)Chitosan malate concn (mg/ml)Log CFU/ml at 24 hMean concn (μg/ml) ± SDa
SAgDelta-hemolysin
587 (TSST-1)09.95.8 ± 0.758 ± 12
0.59.91.6 ± 0.922 ± 3.6
1.09.80.8 ± 0.22.0 ± 1.3
3.59.30.2 ± 0.10.5 ± 0.3
7.0<1.0<0.06<0.01
MN PA (TSST-1)09.436 ± 5.741 ± 5.3
0.59.418 ± 3.124 ± 1.7
1.09.49.7 ± 1.04.0 ± 1.5
3.58.90.6 ± 0.20.05 ± 0
7.0<1.0<0.06<0.01
MN Ho (SEB)09.779 ± 5.561 ± 4.4
0.59.752 ± 3.545 ± 3.5
1.09.710 ± 5.75.0 ± 1.5
3.59.60.6 ± 0.20.6 ± 0.4
7.0<1.0<0.06<0.01
MN Don (SEC)09.850 ± 6.054 ± 7.2
0.59.822 ± 2.323 ± 7.5
1.09.88.7 ± 1.25.0 ± 2.1
3.59.82.3 ± 1.22.0 ± 1.0
7.0<1.0<0.06<0.01
  • a The P values for all chitosan malate cultures were <0.01 compared to untreated controls. The SAg and delta-hemolysin concentrations were determined by ELISA.