TABLE 1.

Comparative efficacies of AM 7359 and linezolid against MSSA Smith in an organ burden assay

Compound (mode of administration) and MIC (μg/ml)Dose (mg/kg/day)% MortalityaLog CFU/g of kidneyb (% eradication)Reduction (SD)c
AM 7359 (p.o.), 0.1252503.11* (0)5.23 (0.58)
12.505.41* (0)2.93 (0.59)
6.2505.71* (0)2.63 (0.80)
3.1208.60 (0)−0.26 (0.37)
Linezolid (p.o.), 2.02502.27* (100)6.07 (0.04)
12.505.63* (0)2.71 (0.37)
6.2506.90* (0)1.44 (0.59)
3.1208.87 (0)−0.53 (0.10)
AM 7359 (i.v.), 0.1252503.81* (0)4.59 (0.15)
12.503.94* (0)4.46 (0.16)
6.2506.37* (0)2.03 (0.61)
3.1208.34 (0)0.06 (0.15)
Linezolid (i.v.), 2.02504.13* (0)4.27 (0.70)
12.506.96* (0)1.44 (1.62)
6.2508.52 (0)−0.12 (0.20)
3.1208.67 (0)−0.27 (0.11)
Control (distilled H2O; p.o.)208.34 (0)
Control (distilled H2O; i.v.)08.40 (0)
  • a Calculated as the number dead divided by the total number in the group.

  • b *, significant reduction compared to sham-treated control as determined by Student's t test.

  • c Reduction in log number of CFU compared to sham-treated control. Significant reductions are shown in bold. SD, standard deviation of results for the four mice per group.