TABLE 2.

Distributions of phenotypes, genotypes, and antimicrobial resistance patterns of 125 erythromycin-resistant S. pneumoniae isolates

Phenotypea (no. of isolates)MIC range (μg/ml)Resistance patternbNo. of isolatesNo. of isolates with resistance determinant
ErythromycinClindamycinJosamycinerm(B)mef(E)mef(A)tet(M)
Constitutive MLSB (91)>32>0.5>2Penr Eryr Clir Josr Chlr SxTr Tetr26261026
Penr Eryr Clir Josr Chls SxTr Tetr23231023
Penr Eryr Clir Josr Chls SxTs Tetr13130013
Pens Eryr Clir Josr Chlr SxTr Tetr88108
Pens Eryr Clir Josr Chls SxTs Tetr88108
Pens Eryr Clir Josr Chls SxTr Tetr55005
Pens Eryr Clir Josr Chls SxTs Tets33000
Penr Eryr Clir Josr Chls SxTr Tets22101
Penr Eryr Clir Josr Chls SxTs Tets11000
Penr Eryr Clir Josr Chlr SxTs Tetr11000
Penr Eryr Clir Josr Chlr SxTr Tets11000
Inducible MLSB (18)4->320.5->0.5>2Penr Eryr Clir Josr Chlr SxTr Tetr55005
Penr Eryr Clir Josr Chls SxTr Tetr88108
Penr Eryr Clir Josr Chls SxTs Tetr22002
Penr Eryr Clir Josr Chls SxTs Tets11000
Pens Eryr Clir Josr Chlr SxTr Tetr11001
Pens Eryr Clir Josr Chls SxTr Tets11000
M (16)2-32≤0.25≤0.5Penr Eryr Clis Joss Chls SxTr Tets60600
Pens Eryr Clis Joss Chls SxTs Tets60420
Penr Eryr Clis Joss Chls SxTs Tets20200
Penr Eryr Clis Joss Chls SxTs Tetr10101
Penr Eryr Clis Joss Chlr SxTs Tets10100
  • a According to the results of the double-disk diffusion method (6).

  • b According to the results of the broth microdilution method.