TABLE 1.

In vitro antimicrobial activities of FQs and CLR against 76 clinically isolated MAC strains and 2 reference MAC strains

MAC clinical isolate (n = 76)MIC (μg/ml)b
MXFGATLVXCLR
M. avium JATA51-012242
M. intracellulare JATA52-010.5140.5
MAC N016a0.50.522
MAC N018a0.5140.5
MAC N084a0.5180.5
  • a Strain used in subsequent in vivo experiments.

  • b Ranges were ≤0.125 to 8, ≤0.125 to 8, ≤0.125 to 64, and ≤0.125 to >128, and MIC90s were 2, 4, 16, and 64 μg/ml for MXF, GAT, LVX, and CLR, respectively.