TABLE 1.

Dosing scheme in experiments to determine effect of rifampin dose scheduling on Mycobacterium tuberculosis resistance

Rifampin dosing schemeDrug exposures achieved in the following HFS:
12345
AUC0-24 (mg·h/liter) in HFSs treated with rifampin daily (n = 5)01248
AUC0-168 (mg·h/liter) in HFSs treated with rifampin once a wk (n = 3)142856
Cumulative AUC (mg·h/liter) for 7 days07142856