TABLE 2.

Echinocandin inhibition of growth and GS with wild-type and mutant strains

StrainMEC (μg/ml)aIC50 (ng/ml)b
CSFANFMCFCSFANFMCF
KU80Δ0.250.0150.0150.910.240.63
EMFR-S678P>1616>16109.7029.1712.61
EMFR-S678P/ WT>16880.12, 104.90.37, 29.890.50, 14.38
  • a Geometric means (three repetitions from separate preparations) are given.

  • b Multiple IC50 values reflect kinetic parameters for mixed wild-type and mutant enzyme populations.