TABLE 3

Final population pharmacokinetic parameters of azithromycin and bootstrap resultsa

ParameterFull data setBootstrap
Final estimateRSE (%)Median5th–95th
CL (liters/h)
CL = θ1 × (wt/21.5)0.75 × θ5** Fliver27.87.127.122.5–30.4
    θ1
    If ALT ≤ 40, Fliver = 0
    If ALT > 40, Fliver = 10.76114.70.7960.584–1.05
    θ5
V1 (liters)
    V1 = θ2 × (wt/21.5)39.543.832.614.2–62.6
    θ2
V2 (liters)
    V2 = θ3 × (wt/21.5)37713.4375221–491
    θ3
Q (liters/h)
    Q = θ4 × (wt/21.5)0.7555.722.451.426.4–73.8
    θ4
Interindividual variability (%)
    CL32.125.228.911.3–36.5
    V184.941.282.631.4–123
    Q51.629.446.49.8–63.2
Residual variability (%)5.7161.67.22.2–30.5
  • a RSE, relative standard error; wt, body weight in kilograms; Fliver, scaling factor applied for patients with impaired hepatic function. In our population, 21.5 kg is the median body weight.