TABLE 2

Parameter estimates for the final population pharmacokinetic models for rifampin and isoniazida

DrugParameterbEstimate (RSE, %)IIV (% CV)
RifampinFr (proportion)0.0878 (34)1.08 (148.7)
Tk0 (h)0.342 (19)0.914 (114.3)
ka (h−1)0.645 (14)0.464 (49)
V/F (liters)13.8 (10)0.217 (22)
CL/F (liters/h)7.53 (5)0.547 (59.1)
Constant a0.0476 (14)
Slope b0.202 (7)
Isoniazidka (h−1)4.23 (6)0.567 (61.6)
CL/Fslow (liters/h)4.44 (5)0.324 (33.3)
CL/Fnonslow (liters/h)8.08 (6)0.48 (50.9)
V1/F (liters)16.6 (4)0.241 (24.5)
Q/F (liters/h)8.46 (21)0.637 (70.7)
V2/F (liters)1.07 (44)1.9 (599.7)
Constant a0.0393 (19)
Slope b0.193 (6)
  • a All pharmacokinetic parameters are expressed as median (relative standard error [RSE]). IIV, interindividual variability; CV, coefficient of variation.

  • b The residual error modes used in this study consist of the slope b and constant a. The equations are y = f + bfε (proportional) and y = f + (a + bf)ε (combined 1), where f is the structural model and ε is the residual error standardized by Gaussian random variables.