TABLE 3

Most relevant mutations identified in telavancin-resistant mutants

GeneLocusFunctionaSNPAmino acid change
TMH 5007AMT 0114-48ATCC 25913WIS 664Seattle_90
acuCSA1556NAD-independent protein deacetylase AcuCA>TA>TA>TA>TA>TI159L
adh1SA0562Alcohol dehydrogenaseG>TG>TG>TG>TG>TK325N
aldSA1531Alanine dehydrogenaseG>AG>AG>AG>AG>AS126L
capBSA0145Capsular polysaccharide synthesis enzyme Cap5AT>CT>CT>CT>CT>CC81R
ebhASA1267Putative staphylococcal surface-anchored proteinA>GA>GA>GA>GA>GV4497A
fniSA2136Isopentenyl diphosphate delta-isomerase, FMN dependentG>CG>CG>CG>CG>CR88G
gltBSA0430Glutamate synthase (NADPH) large chainT>CT>CT>CT>CT>CV1177A
holASA1415DNA polymerase III delta subunit (EC 2.7.7.7)T>GT>GT>GT>GT>GK45T
hsdMSA0391Type I restriction-modification system, DNA methyltransferase subunit MT>CT>CT>CT>CT>CV387A
lacESA1992PTS system, lactose-specific IIB componentT>CT>CT>CT>CT>CI365 M
lytH, SA1459SA1458LytH protein involved in methicillin resistance/N-acetT>CT>CT>CT>CT>CI1F
mutS2SA0991Recombination inhibitory protein MutS2G>AG>AG>AG>AG>AV252I
pbp2SA1283Multimodular transpeptidase-transglycosylaseG>AG>AG>AG>AG>AC197Y
pbuXSA0374Xanthine permeaseT>GT>GT>GT>GT>GL231V
pgmSA07302,3-Bisphosphoglycerate-independent phosphoglycerate mutaseA>GA>GA>GA>GA>GT250A
rhoSA1923Transcription termination factor RhoT>GT>GT>GT>GT>GI48L
rplASA0496LSU ribosomal protein L1p (L10Ae)A>GA>GA>GA>GA>GT92A
rpsQSA2038SSU ribosomal protein S17pT>AT>AT>AT>AT>AI77L
sigASA1390RNA polymerase sigma factor RpoDC>TC>TC>TC>TC>TV253I
sdrCSA0519Adhesin of unknown specificity SdrCG>AG>AG>AG>AG>AE75K
sdrDSA0520Adhesin of unknown specificity SdrDG>TG>TG>TG>TG>TD1141Y
sucASA12452-Oxoglutarate dehydrogenase E1 componentT>GT>GT>GT>GT>GK842N
tagGSA0594Teichoic acid translocation permease protein TagGT>CT>CT>CT>CT>CV227A
tcaASA2146Membrane protein TcaA, associated with teicoplanin resistanceA>GA>GA>GA>GA>GL218P
thrSSA1506Threonyl-tRNA synthetaseC>TC>TC>TC>TC>TG60E
trePSA0432PTS system, trehalose-specific IIB componentC>GC>GC>GC>GC>GA381G
uvrASA0714Excinuclease ABC subunit AT>CT>CTA>CGT>CTA>CGL857P
murQSA0185N-Acetylmuramic acid 6-phosphate etheraseC>TG257D
clfASA0742Clumping factor ClfA, fibrinogen-binding proteinC>AP208T
dltASA0793d-Alanine–poly(phosphoribitol) ligase subunit 1A>GK177E
dltASA0793d-Alanine–poly(phosphoribitol) ligase subunit 1G>AS275N
dltASA0793d-Alanine–poly(phosphoribitol) ligase subunit 1T>CL318P
dltASA0793d-Alanine–poly(phosphoribitol) ligase subunit 1C>AD327E
dltDSA0796Poly(glycerophosphate chain) d-alanine transfer protein DltDT>AI264K
dltDSA0796Poly(glycerophosphate chain) d-alanine transfer protein DltDT>AD350E
spaSA0107Protein A, von Willebrand factor binding protein SpaCC>TTG321N
spaSA0107Protein A, von Willebrand factor binding protein SpaT>GK274N
spaSA0107Protein A, von Willebrand factor binding protein SpaGT>AGN234T
  • a FMN, flavin mononucleotide; PTS, phosphotransferase; N-acet, N-acetyl; LSU, long subunit; SSU, short subunit.