TABLE 1

ITC data showing binding of leucine and AN2690 to LdLRS

LigandKd (μM)ΔH (kcal/mol)TΔS (kcal/mol)ΔG (kcal/mol)N valuea
Leucine43 ± 5+4.6 ± 0.5+10.6 ± 0.35−6.01.06
AN2690231 ± 45+4.3 ± 0.24+9.2 ± 0.81−4.90.98
  • a The N value from the one-site model.