TABLE 1

Demographics of children with TB

CharacteristicNo. or median value (IQR)
Total no. of patients113
Age (yr)5.00 (2.17–8.25)
Wt (kg)14.3 (9.70–20.1)
Serum creatinine (μmol/liter)36.0 (27.3–47.8)
Sex
    Male63
    Female50
HIV infection
    Positive59
    Negative54
NAT2 genotype
    Slow51
    Intermediate50
    Fast12
Dose (mg/kg)
    Rifampin15.8 (13.6–18.8)
    Isoniazid11.0 (9.06–12.8)
    Pyrazinamide24.7 (22.6–29.7)
    Ethambutol16.8 (15.0–20.3)
Wt band (kg) in simulation (n)
    5–7 (16,000)Wt (kg): 6.45 (6.17–7.25)
Age (yr): 0.960 (0.650–1.42)
    8–14 (41,000)Wt (kg): 12.5 (10.1–13.4)
Age (yr): 4.00 (2.17–5.00)
    15–20 (27,000)Wt (kg): 17.7 (16.0–19.5)
Age (yr): 6.50 (5.25–8.92)
    21–30 (21,000)Wt (kg): 22.4 (21.9–24.2)
Age (yr): 9.83 (8.25–11.92)