TABLE 3

Haplotypes of Pfcrt and Pfmdr1 during 2011 to 2016a

YearSamplesPfcrtcPfmdr1c
No. of isolatesWTb (CVMNK) (no. [%])Mutation (no. [%])Mixed type (CV M/I N/E K/T) (no. [%])No. of isolatesWT (NY) (no. [%])Mutation (no. [%])Mixed type (no. [%])
PCR positiveSequencedCVIETSVMNTPCR positiveSequencedYYNFYFN Y/FY Y/F
Total21120917689 (50.57)44 (25.00)2 (1.14)41 (23.30)21119365 (33.68)12 (6.22)71 (36.79)27 (13.99)14 (7.25)4 (2.07)
20117773 (42.86)4 (57.14)0 (0.00)0 (0.00)762 (33.33)0 (0.00)1 (16.67)2 (33.33)1 (16.67)0 (0.00)
201233332513(52.00)7 (28.00)1 (4.00)4 (16.00)33308 (26.67)4 (13.33)11 (36.67)4 (13.33)1 (3.33)2 (6.67)
20134543237 (30.43)12 (52.17)1 (4.35)3 (13.04)454210 (23.81)2 (4.76)20 (47.62)8 (19.05)1 (2.38)1 (2.38)
201437373318 (54.55)7 (21.21)0 (0.00)8 (24.24)373714 (37.84)3 (8.11)12 (32.43)7 (18.92)1 (2.70)0 (0.00)
201539393919 (48.72)8 (20.51)0 (0.00)12 (30.77)39359 (25.71)0 (0.00)15 (42.86)6 (17.14)4 (11.43)1 (2.86)
201650504929 (59.18)6 (12.24)0 (0.00)14 (28.57)504322 (51.16)3 (6.98)12 (27.91)0 (0.00)6 (13.95)0 (0.00)
Z (observed value)1.2522.7241.9021.7212.2741.111.0911.9232.3971.59
P value0.2110.006d0.0570.0850.023d0.2670.2750.0540.017d0.112
  • a The haplotypes were constructed considering codon positions 72 to 76 of Pfcrt and codon positions 86 and 184 of Pfmdr1.

  • b WT, wild type.

  • c Amino acid mutations are underlined.

  • d The difference is statistically significant.