Drug | Parameter^{b} | Estimate (RSE, %) | IIV (% CV) |
---|---|---|---|

Pyrazinamide | MTT (h) | 0.33 (9) | 0.443 (46.6) |

K_{tr} (h^{−1}) | 12.5 (11) | 0.455 (48.0) | |

N | 3.13 | ||

k (h_{a}^{−1}) | 5.28 (7) | 2.05 (811.5) | |

V/F (liters) | 13.1 (4) | 0.37 (38.3) | |

Exponent (BW on V/F) | 0.677 (11) | Fixed | |

CL/F (liters/h) | 1.6 (4) | 0.385 (40.0) | |

Exponent (BW on CL/F) | 0.735 (10) | Fixed | |

Constant a | 0.268 (23) | ||

Slope b | 0.112 (7) | ||

Ethambutol | T_{lag} (h) | 0.723 (7) | 0.174 (17.5) |

T_{k}_{0} (h) | 0.9 (16) | 0.605 (66.5) | |

CL/F (liters/h) | 32.5 (5) | 0.458 (48.3) | |

Exponent (BW on CL/F) | 0.382 (24) | Fixed | |

V_{1}/F (liters) | 112 (7) | 0.607 (66.7) | |

Exponent (BW on V_{1}/F) | 0.228 (84) | Fixed | |

Q/F (liters/h) | 15.4 (10) | 0.274 (27.9) | |

Exponent (BW on Q/F) | 0.474 (44) | Fixed | |

V_{2}/F (liters) | 97.8 (8) | 0.31 (31.8) | |

Exponent (BW on V_{2}/F) | 0.858 (60) | Fixed | |

Slope b | 0.272 (6) |

↵a All pharmacokinetic parameters are expressed as median (relative standard error [RSE]). IIV, interindividual variability; CV, coefficient of variability; BW, body weight. MTT, mean transit time.

↵b The residual error modes used in this study consist of the slope

*b*and constant*a*. The equations are*y*=*f*+*bf*ε (proportional) and*y*=*f*+ (*a*+*bf*) ε (combined 1), where*f*is the structural model and ε is the residual error standardized by Gaussian random variables. The mean transit time was calculated as follows: MTT = (*N*+ 1)/*K*_{tr}, where*N*and*K*_{tr}represent the number of compartments and transit rate constant, respectively.