TABLE 2

Covariate analysisa

ParameterPK parameter(s)Objective function value
Structural model1,477.506
Body wt (allometric model)CL + V1 + V2 + Q1,443.629
Impact of ageCL1,443.747
V11,443.648
V21,434.236
Q1,437.701
V2 + Q1,442.732
Impact of liver function, ALTCL1,432.51
Impact of renal function, serum creatinineCL1,443.622
Impact of sexCL1,437.551
V11,443.419
V21,443.692
Q1,443.692
Impacts of age and liver functionV2 (age) + CL (AST)1,431.775
Impacts of age and sexV2 (age) + CL (sex)1,434.24
Impacts of liver function and sexCL (AST) + CL (sex)1,436.548
Impacts of age, liver function, and sexV2 (age) + CL (AST) + CL (sex)1,434.898
  • a CL, clearance; V1, central volume of distribution; V2, peripheral volume of distribution; Q, intercompartment clearance; ALT, alanine aminotransferase; AST, aspartate aminotransferase.