TABLE 4

Polymorphisms of Pfmdr1 and K13-propeller in Plasmodium falciparum isolates

Gene (ID)ReferenceaMutationbNo. of isolatesPrevalence (% [95% CI])d
Codon positionAAcCodonAACodonBase positionPCR positiveSequencedWith mutation
pfmdr1 (PF3D7_0523000)102GggtGggC30642.07 (0.06–4.08)
102GggtGggC/T30642.07 (0.06–4.08)
130EgaaK/EA/Gaa38821119310.52 (−0.49–1.53)
156DgatNAat46610.52 (−0.49–1.53)
182GggtGggG54610.52 (−0.49–1.53)
182GggtGggG/T54610.52 (−0.49–1.53)
1069TactTacG3207115.29 (2.25–8.33)
1069TactTacG/T320720.96 (−0.37–2.29)
1113GggtAgCt333821120810.48 (−0.46–1.42)
1142PcctPccA342610.48 (−0.46–1.42)
1157TacaTacG347110.48 (−0.46–1.42)
1196DgatNAat358620.96 (−0.37–2.29)
1226FtttYtAt367710.48 (−0.46–1.42)
1230GggaGggC369010.48 (−0.46–1.42)
k13-propeller (PF3D7_1343700)550StctStcC165019918421.09 (−0.41–2.59)
561RcgtHcAt168210.54 (−0.52–1.6)
575RagaR/KaA/Ga172410.54 (−0.52–1.6)
589VgtcIAtc176510.54 (−0.52–1.6)
  • a Reference sites are underlined.

  • b Mutation sites are underlined.

  • c AA, amino acid residue.

  • d CI, confidence interval.