TABLE 4

Prevalence of high-BLNAR isolates in Japan and other countries

CountryYear(s) of isolationNo. (%) of H. influenzae isolatesHigh-BLNAR strains among BLNAR strains (%)Reference
TotalBLNARaHigh-BLNARb
Japan2016–201810462 (59.6)57 (54.8)91.9This study
2011–201212257 (46.7)c52 (42.6)91.222
2004–200517261 (35.5)c43 (25.0)70.523
2003264172 (65.2)c74 (28.0)43.013
2002–2004457211 (46.2)c121 (26.5)57.342
2000–2009508247 (48.6)c159 (31.3)55.320
199929678 (26.3)c39 (13.1)50.015
1995–2003621229 (36.9)77 (12.4)33.66
1987–200016222 (13.6)c3 (1.9)13.619
Korea201212249 (40.2)18 (14.8)36.78
Norway2007808116 (14.4)3 (0.4)2.614
Korea2005–200654033 (6.1)8 (1.5)33.321
Portugal2001–200824094 (39.1)2 (0.8)2.19
Spain2001–2006354198 (55.9)12 (3.4)6.17
France2000–20082,206354 (16.0)3 (0.14)0.911
Spain2000–20099527 (28.4)0 (0)010
Korea2000–200522967 (29.3)0 (0)018
United States19999513 (13.7)c0 (0)015
  • a Isolates with Arg517His or Asn526Lys substitutions in PBP3.

  • b Isolates with Ser385Thr in addition to Arg517His or Asn526Lys substitutions in PBP3.

  • c Defined by PCR.