TABLE 3

Comparison of observed human exposures and predicted murine exposures of human-simulated regimensa

Human dose (mg/kg q24h)fAUC0–24 observed (mg · h/liter)Murine regimen (mg/kg HSR)fAUC0–24 predicted (mg · h/liter)
653.7 ± 6.6660.8
872.9 ± 18.1875.7
1088.3 ± 15.11094.6
  • a q24h, every 24 h; HSR, human-simulated regimen.