TABLE 4

Metabolic stability of sPBTZ derivatives measured in mouse and human microsomes

CompoundCLint (μl/min/mg protein)Source or reference
Mouse microsomeHuman microsome
1132605918.616.8This study
113261271921.5This study
116260912.79.7This study
1162609231.4This study
11626093426.4This study
1162609424277This study
116260950.91.0This study
Carbamazepine0.60.4This study
Nifedipine105121.1This study
PBTZ16936.7285
BTZ04316.54.205