TABLE 2

Values of free antibiotic concentrations and changes of α- and β-diversity indices between D0 and D3 according to vital status at D16 in antibiotic-treated groups for each study and their respective areas under the ROC curves for predicting occurrence of death by D16

Antibiotic and parameterMedian (minimum, maximum) value for mice that:P valuecAUROC (95% CI)
DiedaSurvivedb
Moxifloxacin
    Concn110.0 (70.5, 172.7)52.9 (0.0, 162.1)0.000250.87 (0.76, 0.95)
    α diversity
        Change of Shannon index−1.7 (−3.0, −1.0)−1.0 (−1.9, 0.1)<10−40.91 (0.80, 0.98)
        Change of no. of OTUs−135.9 (−207.3, −52.2)−72.9 (−201.0, 74.5)0.0010.83 (0.67, 0.95)
        Change of Chao1 index−137.9 (−213.4, −46.2)−75.5 (−229.3, 83.5)0.0020.81 (0.64, 0.93)
    β diversity
        UniFrac distance
            Unweighted0.61 (0.56, 0.76)0.51 (0.37, 0.65)<10−50.95 (0.90, 0.99)
            Weighted0.33 (0.24, 0.48)0.26 (0.13, 0.57)0.020.73 (0.58, 0.87)
        Bray-Curtis dissimilarity0.78 (0.63, 0.86)0.60 (0.31, 0.87)<10−40.91 (0.81, 0.99)
Clindamycin
    Concn5.0 (0.0, 37.8)0.0 (0.0, 4.4)<10−60.81 (0.72, 0.91)
    α diversity
        Change of Shannon index−2.2 (−4.3, −0.4)−1.1 (−2.6, 0.0)<10−60.88 (0.78, 0.96)
        Change of no. of OTUs−223.9 (−344.6, −75.8)−106.8 (−202.2, −22.0)<10−50.86 (0.75, 0.95)
        Change of Chao1 index−227.7 (−358.2, −73.8)−110.0 (−209.0, −22.7)<10−60.86 (0.76, 0.95)
    β diversity
        UniFrac distance
            Unweighted0.71 (0.59, 0.84)0.60 (0.49, 0.68)<10−100.94 (0.88, 0.99)
            Weighted0.42 (0.24, 0.62)0.30 (0.24, 0.59)<10−60.87 (0.76, 0.96)
        Bray-Curtis dissimilarity0.86 (0.71, 0.98)0.70 (0.61, 0.87)<10−90.92 (0.84, 0.97)
  • a n = 10 for the moxifloxacin study and 28 for the clindamycin study.

  • b n = 60 for the moxifloxacin study and 32 for the clindamycin study.

  • c By the nonparametric Wilcoxon test.