TABLE 1

Mortality rates, fecal counts of C. difficile at D3, fecal concentrations of active antibiotic at D3, change of Shannon index between D0 and D3, and unweighted UniFrac distances between D0 and D3 according to treatment groups in the moxifloxacin and clindamycin studies

AntibioticTreatment groupnMortalityC. difficile countsConcnbShannon indexUniFrac
No. (%)q or P valueaLog10 CFU/g, median (minimum, maximum)q or P valueμg/g, median (minimum, maximum)q or P valueChange, median (minimum, maximum)q or P valueUnweighted distance, median (minimum, maximum)q or P value
MoxifloxacinControls100 (0)3.2 (3.2, 3.2)−0.1 (−0.6, 2.3)0.28 (0.24, 0.69)
MXF/01010 (100)7.7 (6.9, 8.0)110.0 (70.5, 172.7)−1.7 (−3.0, −1.0)0.61 (0.56, 0.76)
MXF/200200 (0)<10−73.2 (3.2, 5.3)<10−494.6 (43.0, 162.1)0.14−1 (−1.9, 0.1)0.000650.56 (0.49, 0.65)0.00075
MXF/300200 (0)<10−73.2 (3.2, 4.8)<10−457.2 (20.2, 107.4)<10−4−1 (−1.5, −0.2)0.000260.51 (0.45, 0.57)<10−6
MXF/600100 (0)<10−43.2 (3.2, 4.6)<10−54.2 (1.1, 20.3)<10−4−0.8 (−1.3, −0.3)0.000230.45 (0.42, 0.56)<10−4
MXF/900100 (0)<10−43.2 (3.2, 3.2)<10−50.0 (0.0, 1.3)0.00033−0.8 (−1.6, −0.2)0.00220.41 (0.37, 0.51)<10−4
All groups8010 (12.5)<10−113.2 (3.2, 8.0)<10−859.4 (0.0, 172.7)<10−9−1 (−3, 2.3)<10−50.51 (0.24, 0.76)<10−9
ClindamycinControls90 (0)3.2 (3.2, 3.2)0.0 (−0.3, 0.5)0.31 (0.27, 0.38)
CLI/01010 (100)7.6 (4.3, 7.8)10.1 (0.0, 37.8)−3.9 (−4.3, −2.6)0.77 (0.72, 0.84)
CLI/300109 (90)>0.996.1 (3.2, 7.8)0.0754.2 (0.0, 14.2)0.061−2.1 (−2.6, −1.5)<10−40.69 (0.62, 0.74)<10−4
CLI/450106 (60)0.114.9 (3.2, 8.0)0.0660.0 (0.0, 6.5)0.0041−1.4 (−2.5, −1.0)<10−40.66 (0.63, 0.71)<10−4
CLI/600103 (30)0.00523.9 (3.2, 5.3)0.00410.0 (0.0, 30.0)0.024−1.1 (−1.6, −0.4)<10−40.61 (0.55, 0.65)<10−4
CLI/750100 (0)<10−44.7 (3.2, 6.0)0.00740.0 (0.0, 0.0)0.0019−0.8 (−1.4, 0.0)<10−40.57 (0.55, 0.61)<10−4
CLI/900100 (0)<10−43.6 (3.2, 4.6)0.00410.0 (0.0, 0.0)0.0019−0.9 (−1.5, 0.7)<10−40.57 (0.49, 0.63)<10−4
All groups6928 (40.6)<10−104.4 (3.2, 8.0)<10−50.0 (0.0, 37.8)<10−4−1.1 (−4.3, 0.5)<10−90.62 (0.27, 0.84)<10−10
  • a q values refer to the comparison of the corresponding treatment group with the antibiotic-plus-DAV131A placebo treatment group (MXF/0 or CLI/0), after Benjamini-Hochberg correction. The P values for the comparison of all treatment groups using the Fisher exact test or Kruskal-Wallis test are reported in the “All groups” lines.

  • b In the analysis of concentrations, only antibiotic-treated groups were included.